Design of compounds combining various fragments affecting tubulin polymerization and depolimerization as promising oncolytic agents
Tubulin is a building block of microtubules that are formed during cell division. Disruption of its polymerizationa and depolymerization is a promising strategy of fighting oncological diseases.
We develop interesting compounds that combine various tubulin-active structural blocks, e.g., fragments of taxol, colchicin and their analogs.
O. N. Zefirova et al. Bioorg. Med. Chem. 2011, 19, 5529
O. N. Zefirova et al. ChemBioChem. 2013, 14, 1444